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细胞因子诱导的杀伤细胞的研究进展 被引量：2

Review of cytokine induced killer cells
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摘要 细胞因子诱导的杀伤细胞 (cytokineinducedkiller ,CIK)是一种非MHC限制性的新型免疫活性细胞 ,其增殖能力强、杀瘤活性高、副作用小 ,优于淋巴因子激活的杀伤细胞 (LAK) ,对于提高患者自身抗肿瘤免疫能力有重要作用。 Cytokine induced killer (CIK) is a new kind of immune cells which have non MHC restriction,highly proliferation and cytotoxicity.Their activities are superior to lymphokine activated killer cells.Immunotherapy of CIK cells can significantly improve clinical symptoms,but hardly have any side effects.CIK cells also can improve antitumor effects of patients.
作者 李曼 孙载阳 陈宝安
机构地区 东南大学附属中大医院血液科
出处 《现代医学》 2004年第2期132-135,共4页 Modern Medical Journal
基金 江苏省自然基金 (BK991 2 6)
关键词 细胞因子 诱导 杀伤细胞 研究进展 肿瘤 临床应用 cytokine induced killer cells carcinoma clinical application
分类号 R392.11 [医药卫生—免疫学]
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参考文献15

  • 1康自珍,蔡海波,秦晓亮,徐莉,谭文松.用无血清培养基体外扩增CIK细胞的研究[J].中华微生物学和免疫学杂志,2002,22(1):81-81. 被引量：5
  • 2ZOLL B,LEFTEROVA P,EBERT O,et al.Modulation of call surface markers on NK-like T lymphocytes by using IL-2,IL-7or IL-12 in vitro stimulation[J].Cytokine,2000,12(3):1385-1390.
  • 3ZOLL B,LEFTEROVA P,CSIPAI M,et al.Generation of cytokine-induced killer cells using exogenous interleukin-2,-7or12[J].Cancer Immunol Immunother ,1998,47(3):221-226.
  • 4MARTEN A,ZISKE C,SCHOTTKER B,et al.Interactions between dendritic cells and cytokine-induced killer cells lead to an activation of both populations[J].J Immunother,2001,24(5):502-510.
  • 5MARTEN A,RENOTH S,von LILIENFELD-TOAL,et al.Enhanced lytic activity of cytokine-induced killer cells against multiple myeloma cells after co-culture with idiotype-pulsed dendritic cells[J].Haematologica,2001,86(7):1029-1037.
  • 6FINKE S,TROJANECK B,LEFTEROVA P,et al.Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3 + CD56 + immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene[J].Gene Ther,1998,5(4):31～39.
  • 7任欢,邢淑贤,周贵生,王立荣,田景先,李殿俊.CIK细胞与LAK细胞对H-22腹水瘤的抑瘤作用[J].哈尔滨医科大学学报,2000,34(2):85-87. 被引量：5
  • 8Fu-Sheng Wang Ming-Xu Liu Bing Zhang Ming Shi Zhou-Yun Lei Wen-Bing Sun Qing-You Du Ju-Mei Chen,Division of Biological Engineering,Beijing Institute of Infectious Diseases,Beijing 100039,China Wen-Bing Sun,Department of Surgery,Beijing Hospital of Infectious Diseases,Beijing 100039,China.Antitumor activities of human autologous cytokineinduced killer(CIK)cells against hepatocellular carcinoma cells in vitro and in vivo[J].World Journal of Gastroenterology,2002,8(3):464-468. 被引量：108
  • 9白艳艳,缪竞诚,郝福荣,苏丽萍,罗俊鹏,张占英,张澜生.脐血LAK与CIK细胞杀伤活性研究[J].苏州医学院学报,2000,20(6):515-516. 被引量：3
  • 10ALVARNAS J C,LINN Y C,HOPE E G,et al.Expansion of cytotoxic CD3+ CD56+ cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation[J].Biol Blood Marrow Transplant,2001,7(4):216-222.

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现代医学
2004年 第2期

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