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髓性过氧化物酶与动脉粥样硬化相关性研究进展 被引量：3

Relationship between myeloperoxidase and atherosclerosis
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摘要 髓性过氧化物酶是由活化的吞噬细胞分泌的相对分子质量为 75× 2kDa的一种血红素蛋白。它能通过作用于氯化物和酪氨酸 ,分别生成次氯酸和酪氨酰基 ,启动低密度脂蛋白的过氧化 ,产生氧化型低密度脂蛋白 。 Myeloperoxidase is a kind of hemoprotein(molecular weight 75×2?kDa) secreted from activated phagocyte.It can act on chloride and tyrosine to form hypochlorous acid and tyrosyl which can initiate the pro oxidation of lowdensity lipoprotein and promote the development of atherosclerosis ultimately.
作者 张正生 冯毅 刘乃丰
机构地区 东南大学附属中大医院心内科
出处 《现代医学》 2004年第2期136-138,共3页 Modern Medical Journal
关键词 髓性过氧化物酶 动脉粥样硬化 相关性研究 氧化型低密度脂蛋白 myeloperoxidase oxidized low density lipoprotein atherosclerosis
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献18

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同被引文献54

  • 1贾克刚,刘军锋,马明坤,韩雪晶,柴俊岩.血清髓过氧化物酶和高敏C反应蛋白与冠状动脉粥样硬化的相关性研究[J].检验医学,2007,22(2):179-181. 被引量：5
  • 2苏淑红,刘志强,严松彪,陈晖.髓过氧化物酶与急性冠脉综合征[J].北京医学,2007,29(4):235-237. 被引量：6
  • 3Batt KV, Avella M, Moore EH, et al. Differential effects of low-density lipoprotein and chylomicron remnants on lipid accumulation in human macrophages[J]. Exp Biol Med, 2004, 229(6):528-537.
  • 4Kennedy S, Fournet-Bourguignon MP, Breugnot C, et al. Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL[J]. J Vasc Res, 2003,
  • 5Fu T, Borensztajn J. Macrophage uptake of low-density lipoprotein bound to aggregated C-reactive protein: possible mechanism of foam-cell formation in atherosclerotic lesions [J]. Biochem J,2002, 366: 195-201.
  • 6Virella G, Atciley D, Koskinen S, et al. Proatherogenic and proinflammatory properties of immune complexes prepared with purifed human oxLDL antibodies and human oxLDL[J]. Clinical Immunology, 2002, 105(1): 81-92.
  • 7Monaeo C, Paleolog E. Nuelearfactor kappaB: a potential therapeutic target in artheroscleresis and thrombosis[J]. Cardiovase Res, 2004,61:671-682.
  • 8王媛媛,黎莉,周风华,孟晓,钟明,张薇,张运.急性冠状动脉综合征患者外周循环中性粒细胞髓过氧化物酶测定的临床意义[J].山东大学学报（医学版）,2007,45(10):996-999. 被引量：3
  • 9TIBOLLA G,NORATA G D,ARTALI R,et al.Proprotein convertase subtilisin/kexin type 9 (PCSK9): from structure-function relation to therapeutic inhibition. Nutrition, metabolism, and cardiovascular diseases[J].NMCD,2011,21:835-843.
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现代医学
2004年 第2期

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