成人心脏传导系统中连接蛋白43的表达

THE EXPRESSION OF CONNEXIN 43 IN HUMAN CARDIAC CONDUCTION SYSTEM

目的 探讨成人心脏及传导系统窦房结 ,房室结 ,浦肯野纤维中连接蛋白 4 3(CX4 3)的表达情况。 方法 免疫组织化学SABC法。 结果 CX4 3在窦房结及房室结周围细胞膜呈散在、少量表达 ,在浦肯野细胞膜可见线性、细长阳性颗粒 ,在心房及心室肌阳性颗粒主要位于端端相连部位的闰盘处。 结论 CX4 3在传导系统的表达与心脏传导系统的电生理传导特性相符。

Objective To study the expression of connexin 43 in human cardiac conduction system(CCS) and heart. Methods The distribution of CX43 was studied immunohistochemically using of SABC method with antibody CX43. Results Smaller amounts of CX43 can be seen in the nodal myocytes at the periphery of sinoaterial and atrioventricular node whereas in the myocytes at the center of nodes were negative. In the Purkinje fibers, abundant expression of CX43 was found, and in atrial and ventricular myocardium contained abundant amounts of CX43, especially in the intercatalated disk.Conclusion The expression of connexin 43 varies greatly in specific regions of the human heart with different conduction properties. These differences may play a role in regulating electric impulse of cardiac conduction.