摘要
我们在大鼠单核吞噬细胞系统封闭加失血性休克、复苏后造成多器官衰竭的模型上,发现黄嘌呤氧化酶抑制剂别嘌呤醇、能量代谢调节剂果糖-1,6-二磷酸和活血化瘀中药虎杖4号结晶可降低多器官衰竭发生率,延长存活时间,并能不同程度地提高机体的抗氧化能力。我们对它们的作用机制作了初步探讨。
This paper presents a primary study of the treatment of experimental multiple system or- gan failure(MSOF)in rats.The rats were pretreated with xanthine oxidase inhibitor allo- purinol,the energy metabolism regulator fructose-1,6-diphosphate(FDP)and purified Chine- se herbal medicine polydatin.The incidence of MSOF decreased from 71.4% in the untreated group to 35.7%,47.1% and 16.7% in treated groups,respectively,while the mean survival time was prolonged to 38.5h,30.2h and 41.7h in treated groups,respectively,as compared with 26.4h in the untreated gronp.In addition to the known antioxidant effect of the allo- purinol,this study also suggests that FDP and polydatin enhance the capacity of antioxid- tion.
