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人尿中一种抗菌物质三甲氧苄二氨基嘧啶的分离、纯化和鉴定 被引量:3

Separation,Purification and Identification of Trimethoprim——an Antibiotic from Male Urine
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摘要 In order to explain the special antibiotic activity of urine, various chromatographic techniques were applied to separate and purify the key component from the healthy male urine. The structure of purified component was identified by mass spectrometry and NMR. The results indicated that the substance separated from the male urine was trimethoprim. This is the first report of trimethoprim separated from urine. In order to explain the special antibiotic activity of urine, various chromatographic techniques were applied to separate and purify the key component from the healthy male urine. The structure of purified component was identified by mass spectrometry and NMR. The results indicated that the substance separated from the male urine was trimethoprim. This is the first report of trimethoprim separated from urine.
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2004年第2期280-282,共3页 Chinese Journal of Biochemistry and Molecular Biology
基金 江苏省自然科学基金资助项目 (No .BK970 3 6)~~
关键词 人尿 抗菌物质 三甲氧苄二氨基嘧啶 分离 纯化 鉴定 二氢叶酸还原酶 抑制剂 化学药物 细菌感染 urine, trimethoprim,antibiotic,separation and purification
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参考文献8

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二级参考文献2

  • 1贾士荣,马铃薯抗菌肽基因工程,1996年
  • 2Tu Y Z,Sci China,1989年,32卷,1072页

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