宫环Ⅱ号胶囊对宫环出血患者血管舒缩因子的影响

Study on the Effect of GHⅡ on Vessel Factor of Patients with Bleeding after IUD Placement

目的 观察宫环Ⅱ号胶囊(GHⅡ)对宫环出血患者血管舒缩因子的影响。方法 60例气虚血瘀型宫环出血患者完全随机分为GHⅡ治疗组和吲哚美辛对照组,7d为一疗程。采用放射免疫等方法观察宫环出血患者治疗前后子宫内膜组织中CGRP、ET-1及血浆NO、NOS的改变。结果 GHⅡ降低宫环出血患者子宫内膜组织中CGRP及血浆NO水平;升高宫环出血患者子宫内膜组织中ET-1水平。结论 GHⅡ的作用机制与调整局部血管舒缩因子水平、使血管舒缩状态趋于正常有关。

Objective To observe the effect of GHⅡ on vessel factor of patients with Bleeding after IUD Placement. Methods 60 Bleeding after IUD placement patients were randomly divided into two group including GHⅡ treated group (n=30) and western medicine control group (n=30). GHⅡ were orally taken at dose of 16g/d (8g, Bid) in GHⅡ treated group, 1 course including one week. Indomethacin were orally taken at dose of 0.5/d (0.25, Bid) in western medicine control group and the treatment course was same as GHⅡ treated group. Lists of clinical observation were full in after one course. Radio-immunity were adopted to observe alteration of CGRP, ET-1 and level of NO, NOS of plasma. Results Level of NO, CGRP in patients' menorrhea or plasma were decreased. Level of ET-1 in menorrhea was decreased. Conclusion The mechanism of GHⅡ maybe conclude improve level of CGRP, ET-1 and level of NO, NOS in menorrhea or endometrium.