肉芝软珊瑚素全合成的研究——Ⅴ.固-液相转移催化含硫碳负离子烷基化

Studies on the Total Synthesis of Sarcophine Ⅴ. Sulfur-Containing Carbanion Alkylation under Solid-Liquid Phase Transfer Catalysis

固-液相转移催化含硫碳负离子烷基化反应作为关键步骤,完成了肉芝软珊瑚素全合成的闭环。研究了影响产率的不同因素,提出了可能的反应机理。实验结果表明:PEG300～600是合适的固-液相转移催化剂。

This paper reports sulfur-containing carbanion alkylation unber solid-liquid phase transfer catalysis. It is a key step for the total synthesis of sarcophine.The cyclization is completed by this reaction. The effect of factors on the yield are studied and the reaction mechanism is proposed. The results of the experiments show that PEG300～600 are good phase transfer catalysts.