摘要
本文报道了环苯丙-精二肽盐酸盐水合物1的合成及其生理活性研究。作者首次使用DCC/Na_2CO_3合成肽键,无需复杂的纯化,产品纯度较高,产率达83%。本文用此法合成了另外6种二肽。药理试验显示,1对免疫系统有广泛的增强作用并显示出较强的抗肿瘤活性,其机制可能与其免疫促进作用有关。
Cyclo-Phe-Arg hydrochloride 1 from the Chinese soft coral sinularia sp.was synthesized from Z-Phe and NO_2-Arg-OMe with the method of DCC/Na_2CO_3,which haven't been reported. The product had high purity without complicated purification. The yield was 70~80%. The synthesis of seven dipeptides containing NO_2-ArgOMe with the same method was studied. Pharmacological tests showed that 1 had marked immunopotentiation and antitumor activity in animals. We suggest that there might be a relation between these two activities.
出处
《中山大学学报(自然科学版)》
CAS
CSCD
1992年第3期44-48,共5页
Acta Scientiarum Naturalium Universitatis Sunyatseni
关键词
环苯丙
精二肽
盐酸盐
生理活性
soft coral
cyclo-Phe-Arg dipeptide
DCC/Na_2CO_3 method
synthesis
antitumor
immunopotentiation