肝外科中结扎部分肝胆管后相应肝组织保留价值的实验研究

AN EXPERIMENTAL STUDY ON THE VALUE OF PRESERVATION OF THE RELEVANT PORTION OF THE LIVER AFTER LIGATION OF BRANCHES OF THE BILE DUCT IN LIVER SURGERY

本研究观察结扎猪的部分肝胆管后,所出现相应肝组织结构和功能的变化及其合并症如仅结扎胆道分支后,发现相应肝组织逐渐萎缩;到术后3个月,其枯否细胞的吞噬功能和肝细胞线粒体的功能明显减弱,但肝细胞的糖和蛋白质代谢功能变化不显著。被结扎胆管内的胆汁呈无菌状态。表明:在非规则性肝切除或严重肝创伤时,结扎某些肝胆管而保留相应的肝组织,对避免因大块肝组织切除引起的急性肝功能衰竭,有一定的参考价值,但要注意防止胆汁漏的发生。

This study was carried out to investigate the changes of the histological structure and function of the relevant portion of the liver and complications after ligatlon of a branch of the bile duct in pigs. Atrophic changes developed gradually in the involved area after operation. Three months after the operation phagocytic function of the kuppf-fer's cells and functions of mitochondria of liver cells in the relevant portion of the liver reduced remarkably,but the functions of the metabolisms of glucose and protein of liver cells did not change significantly. Bile in the ligated bile duct remained sterile. It was indicated that preservation of the involved portion of the liver was worth while to prevent acute hepatic failure resulting from removal of a large portion of liver tissue in irtegular resection of the liver and severe trauma of the liver. Precaution should be taken to prevent leakage of bile.