乳腺癌患者血及癌组织硒与含硒酶活性的水平

SELENIUM CONTENTS AND SELENIUM-CONTAINED ENZYME ACTIVITY LEVELS IN BLOOD AND CANCEROUS TISSUES OF PATIENTS WITH BREAST CANCER

作者分别测定了女性乳腺癌、乳腺良性病变患者及健康妇女的全血、癌组织、癌旁组织及良性病变组织的硒含量及含硒酶——GSH-PX(谷胱甘肽过氧化物酶)活性水平。结果发现:乳腺癌患者血硒含量及血中GSH-PX活性水平均低于乳腺良性病变患者及健康对照者,乳腺癌组织硒含量却高于癌旁组织及良性病变组织,癌组织的GSH-Px活性水平也高于其自身癌旁组织。本文还探讨了不同临床情况的乳腺癌患者血和癌组织的硒及GSH-PX活性水平。

The selenium (Se) contents and selenium-contained enzyme (glutathione peroxidase, GSH-Px) activity levels in blood, cancerous tissue, para-cancer tissue and benign breast disease tissue of women patients with breast cancer, benign breast diseases and healthy control women were detected. The result showed that the whole blood Se contents and blood GSH-Px activity level of patients with breast cancer were lower than those of the benign diseases and healthy control women. The cancerous tissue Se contents were higher than those of the para-cancer tissue and benign disease tissue. The cancerous tissue GSH-Px activity levels were higher than those of the para-cancer tissue. Besides, the Se and GSH-Px activity level of patients with different stage of breast cancer were also studied.