摘要
在无脊椎动物和脊椎动物发育过程中 ,Notch信号对细胞的命运决定起关键作用。通过Notch受体的信号传递能够扩大并固化相邻细胞之间的分子差异 ,最终决定细胞的命运。本文综述了Notch信号通路的相关细节 。
Notch signaling plays a vital role in cell fate decisions in both invertebrate and vertebrate development. Signals exchanged between neighboring cells through the Notch receptor amplify and consolidate molecular differences, which eventually dictate cell fates. In this review, the details of notch signaling will be discussed, with a focus on Lin/Notch repeats(CSL) independent modes.
出处
《生理科学进展》
CAS
CSCD
北大核心
2004年第2期135-138,共4页
Progress in Physiological Sciences
基金
国家基础研究与发展规划项目 (G19990 5 390 0 )
国家自然科学基金 (30 2 70 5 0 0 )资助课题
