核受体相关因子1的研究进展
The research advance of nuclear receptor Nurr1
摘要
核受体相关因子 1(nuclearreceptor relatedfactor 1,Nurr1)是一种转录因子 ,属于核受体超家族成员 ,主要表达于中脑黑质与腹侧被盖区 ,作为基因转录调控蛋白而参与了中脑多巴胺能神经元的发育与存活、长时记忆、肝再生及炎症等多种生理和病理过程。本文总结和讨论了有关Nurr1的编码基因、分子结构。
出处
《生理科学进展》
CAS
CSCD
北大核心
2004年第2期177-180,共4页
Progress in Physiological Sciences
基金
国家自然科学基金资助课题 (30 0 70 2 4 5 )
参考文献10
-
1[1]Ichinose H, Ohye T, Suzuki T, et al. Molecular cloning of the human Nurr1 gene:characterization of the human gene and cDNAs. Gene,1999,230 233~239.
-
2[2]Xing G, Zhang L, Zhang L, et al. Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs.Kindled seizures. Brain Res Mol Brain Res,1997, 47 251~261.
-
3[3]Aarnisalo P, Kim CH, Lee JW,et al. Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1. J Biol Chem, 2002, 20, 277 35118~35123.
-
4[4]Satoh J, Kuroda Y. The constitutive and inducible expression of Nurr1,a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines. Neuropathology,2002,22 219~232.
-
5[5]Maira M, Martens C, Batsche E,et al. Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment. Mol Cell Biol, 2003, 23 763~776.
-
6[6]Witta J, Baffi JS, Palkovits M,et al. Nigrostriatal innervation is preserved in Nurr1-null mice,although dopaminergic neuron precursors are arrested from terminal differentiation. Brain Res Mol Brain Res,2000,84 67~78.
-
7[7]Chu Y, Kompoliti K, Cochran EJ,et al. Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra. J Comp Neurol,2002, 450 203~214.
-
8[8]Pena de Ortiz S, Maldonado-Vlaar CS, Carrasquillo Y. Hippocampal expression of the orphan nuclear receptor gene hzf-3/nurr1 during spatial discrimination learning. Neurobiol Learn Mem,2000,74 161~178.
-
9[9]Xu PY, Liang R, Jankovic J,et al. Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. Neurology, 2002, 58 881~884.
-
10[10]Le WD, Xu P, Jankovic J,et al. Mutations in NR4A2 associated with familial Parkinson's disease. Nat Genet,2003,33 85~89.
-
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-
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-
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-
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-
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-
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-
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-
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-
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-
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