摘要
目的 研究家族高发性2型糖尿病家系人群中可能的遗传和环境危险因素。方法 对1999~2001年门诊及住院的125个家庭高发性2型糖尿病先证者的家庭成员调查家族信息和环境危险因素,比较2型糖尿病患者、糖耐量减低(IGT)患者与非患者在环境危险因素的差异。采用Falconer法估算遗传度,用Penrose法进行多基因分析研究其遗传危险性。结果 三组人群甘油三酯、体重指数、腰臀比值、高血压史及体力活动史的构成比差异有极显著性(P<0.01),而其他血脂项目及冠心病史差异未见显著性。125个大家系的2型糖尿病遗传度为83.42%±5.84%,提示在这些家系中可能有显性主基因存在。多基因分析研究表明在该人群中,2型糖尿病可能符合多基因遗传模式。结论 2型糖尿病为多基因疾病,环境危险因素和遗传因素及其交互作用可能影响其发病。
Objective To study the risk factors regarding heredity and environment in familial
incident type 2 diabetes mellitus (DM). Methods To compare the difference of environmental risk factors
between type 2 DM, impaired glucose tolerance (IGT) and normal persons through study on familial
information and environmental risk factors in 125 familial incident type 2 DM in-patients and out-patients
from 1999 to 2001. Falconer was used to estimate heritability. Penrose was used to study the heredity
damagers by polygene analysis. Results There was a significant constiuent ratio diversity (P< 0. 01) in
triglyceride, body mass index, waist to hip ratio, hypertension history and physical activities history among
3 groups, while no significant diversity in blood lipids and history of coronary heart disease. 83. 42%±
5. 84% heritability of type 2 DM in 125 familial predigree indicated that dominant major gene might exist
in these familiar pedigrees. Analysis of polygene in these groups showed type 2 DM might conform to the
model of polygene heredity. Conclusion This study suggested that type 2 DM had significant heritability
and genetic heterogeneity, which generally appeared to be a disease of multi--factorial inheritance.
Environmental risk factors, genetic factors and their interactions were due to type 2 DM.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2004年第2期162-164,共3页
Chinese Journal of Epidemiology
基金
江苏省社会发展基金(BS200031)