镧氨羧络合物抑瘤作用的探讨

Antitumor Effects of Some Lanthanum Polyaminocarboxylate Complexes in Vivo

本文观察了几种镧氨羧络合物对小鼠S_(180)和艾氏腹水癌生长的抑制作用及对小鼠的急性毒性。结果发现,DCTA-La和I—LaDCTA对小鼠S_(180)的生长有显著抑制作用,抑瘤率分别为54.8—64.4％(P<0.05,P<0.01)和44.5—51.1％(P<0.05)。提示[LaDCTA]-是一个有效的抗癌结构。但艾氏腹水癌对DCTA-La和I-LaDCTA不敏感(生命延长率<75％)。给小鼠腹腔注药一次,观察一周,各药LD_(50)如下:DCTA—La335.9±32.6mg/kg;NTA—La556.6±55.5mg/kg,I—LaDCTA61.5±7.8mg/kg,I—LaEDTA72.4±9.3mg/kg,I—La-NTA37.7±5.8mg/kg。

The acute toxicities, and the antisumor effects of DCTA-La, EDTA-La, NAT-La,3,6-di-(dimethylamino)-dibenzopyriodonium salts of Lanthanum DCTA EDTA, NTAcomplex anions and formate (I-LaDCTA, I-LaEDTA,I-LaNTA,and IHC-64), in vivo were reported. It was found that: 1.The growth of S_(180) was tignificantly inhibited by DCTA-La and I-LaDCTA, with inhibitory rates 54.8-64.4％ ( P<0.05, P<0.01 ) and 44.5-51.1％ (P<0.05) , respectively. Other structurally similar complexes and IHC-64 showed only weak inhibitory effects with IR<40％. The results suggested that [LaDCTA] was an effective structure of antitumor.The mouse tumor EAC was less sensitive to DCTA-La and -I-LaDCTA. 2. The LD_(50) of DCTA-La NTA-La , I-LaDCTA, I-LaEDTA, and I-LaNTA ( in mouse, i.p., observed for 1 wk ) were as follows respectively: 335.9±32.6mg/kg , 556.6 + 55.5 mg/kg , 61.5±7.8mg/kg,72.4 + 9.4mg/kg and 37.7 + 6.8mg/kg.