氮杂大环化合物在放射性金属标记中的应用研究进展

Recent progress in application of polyazamacrocyclic compounds in radio-metals labeling

氮杂大环化合物可作为双功能螯合剂标记生物分子(一般为小肽,蛋白质或单克隆抗体等),这些放射性金属标记的生物分子为核医学提供了具有广阔应用前景的放射性诊断和放射性治疗药物。综述了氮杂大环化合物在放射性金属标记中的应用研究最新进展,介绍了用于标记的氮杂大环化合物,用于标记的放射性核素,以及标记物的生物学特性。并指出了氮杂大环化合物在不同核素标记中的优缺点。

Polyazamacrocyclic compounds, a group of effective bifunctional chelating agents, have been applied in radio-metals labeling peptides, protein and monoclonal antibodies. Those biomolecules with labeled radio-metals are hopeful of becoming raiopharmaceuticals for radiodiagnosis and radiotherapy. Recent progress in the application of polyazamacrocyclic compounds in radio-metals labeling is summarized. This paper introduces polyazamacrocyclic compounds and, radionuclides used in the radio-metals labeling, and biological characters of the labeled conjugates. Both advantages and disadvantages of polyazamacrocyclic compounds in the labeling with different radionuclides are discussed.