丹参对高原心肌慢性缺氧的保护作用——组织病理学及超微结构的研究

Protective Effects of SMB on Hypoxic Myocardium in Chronic High Altitude Exposure——A Histopathological and Ultrastructural Study

为了进一步探讨在高原条件下慢性心肌缺氧性损伤的病理形态学变化和中药丹参对该损伤的保护作用,本实验用大鼠28只,随机分为实验组(注射丹参组)和对照组(注射生理盐水组)将大鼠于6日内从海平面携入高原(海拔3416m)在该地生存8周后处死,对大鼠心肌的光镜和超微结构的变化进行了观察。结果发现,大鼠心肌呈现较弥漫的损伤,包括心肌细胞本身的病变和心肌微循环障碍两方面。同时观察到丹参对该条件下的心肌损伤具有显著的保护作用。作者推测,丹参的这种作用是通过多种途径实现的,

In order to investigate myocardial histopathological alterations of chro- nic high altitude exposure and pro- tective effects of salvia miltorrhiza Bunge (SMB) on the lesions, 28 rats were used and devided randomly into experimental group(injected with SMB) and control group (injected with pla- cebo). They were carried into plateau (3416m above sea level) from sea level (Shanghai 5 m above sea level) within 6 days. The rats were sacrificed de- capitedly following 8 weeks and the histopathological and ultrastructural altertions were examined. The results show that there were no significant differences between both ventricles and septum in cardiac les- ions, it was found that myocardial lesions of chronic high altitude exp- osure should included both myocardial injury and microcirulatory disturban- ces. The results also show that SMB has significant protective effects to the chronic hypoxic myocardium ex- posed to high altitude.