尿刷状缘酶检测在糖尿病早期肾损害诊断中的价值

Screening value of urinary brush border enzyme for the early renal damage in patients with diabetes

目的:探讨尿刷状缘酶对糖尿病患者早期肾损伤的诊断价值。方法:根据病程将84例糖尿病(dabetes mellitus,DM)患者分为三组:A组病程3年以内,B组病程3～10年之间,C组病程10年以上。检测他们及30例正常对照组的尿N-乙酰-β-D-氨基葡萄糖苷酶(N-acetyl-beta-D-glucosaminidase,NAG)和尿刷状缘酶,后者包括碱性磷酸酶(alkaline、phosphatase,ALP)和亮氨酸氨基肽酶(leucineaminopeptidase,LAP)。结果:DM各组与对照组尿NAG差异有显著性(P<0.05),各组间尿刷状缘酶的差异亦有显著性(P<0.05)。结论:尿刷状缘酶检查可用于早期DM肾损伤的检测。

Objective:To explore the screening value of urinary brush border enzyme for the early renal damage in patients with diabetes.Methods:Eighty-four cases with diabetes,according to their medical history,were divided into three groups:group A had medical history less than 3 years, group B between 3 and 10 years and group C more than 10 years.Urine samples of these patients and 30 normal cases were analyzed for contents of urinary N-acetyl-beta-D-glucosaminidase and urinary brush border enzyme.Results:The levels of both urinary NAG and urinary brush-border enzyme in diabetes mellitus group were significantly higher than those in normal control group(P<0.05).Conclu- sion:The detection of urinary brush boder enzyme is helpful to early diagnosing renal damage of dia- betes mellitus.