加替沙星治疗急性细菌性感染的临床研究

Clinical study on gatifloxacin in the treatment of acute bacterial infections

目的:评价加替沙星治疗急性细菌感染性疾病的临床疗效及安全性。方法:将临床确诊的急性泌尿系统或呼吸系统感染的210例患者随机分成2组,进行双模拟双盲、随机平行对照试验。试验组105例,口服加替沙星400mg,每日1次;对照组口服左旋氧氟沙星200mg,每日2次,疗程7～14d。结果:实验组和对照组临床痊愈率分别为75.24％、73.33％,有效率分别为94.29％、93.33％,细菌清除率分别为92.31％、88.17％,两组之间上述指标均无统计学差异(P>0.05)。结论:加替沙星抗菌谱广,用药方便,治疗急性细菌性感染安全有效。

Objective:To evaluate the clinical safety and efficacy of gatifloxacin in the treat- ment of acute bacterial infections.Methods:In this randomized,doubleblind,comparable controlled study,two hundred and ten patients with acute urinary tract infections or acute respiratory tract infec- tions were evaluated.They were divided into two groups,the trial group were treated with gatiflocxacin 40Omg oral qd and the control group with levofloxacin 200 mg oral bid,both for 7～14 days.Results: The clinical cure rates of two groups were 75.24% and 73.33%,clinical efficacy rates 94.29% and 93.33%,bacterial clearance rates 92.31% and 88.17%,adverse reaction rates 9.25% and 8.57%.All above indicators showed no significant difference between the two groups.Conclusion:Gatifloxacin has a wide anti-bacterial spectrum and can be used conveniently to treat acute bacterial infections for its efficacy and safety.