口服氟铁龙联合环磷酰胺治疗晚期乳腺癌

Oral combination chemotherapy of 5′-Deoxy-5-Fluorouridine (furtulon) and cyclophosphamide for advanced breast cancer

目的 观察口服氟铁龙和环磷酰胺联合方案治疗晚期乳腺癌的疗效与安全性。方法2 0 0 0年 6月～ 2 0 0 2年 6月口服氟铁龙和环磷酰胺联合方案治疗晚期乳腺癌 83例。平均化疗 5个周期 ,中位数 6个周期 (2～ 6个周期 )。结果 完全缓解 4例 ,部分缓解 34例 ,稳定 33例 ,进展 12例 ,总有效率 (CR +PR) 4 5 .8% ,中位肿瘤进展时间 6个月。主要毒性为恶心和呕吐 ,Ⅲ度恶心和呕吐发生率为 2 .4 % (2 83) ,未发生Ⅳ度胃肠道反应。骨髓抑制轻微。结论 口服氟铁龙和环磷酰胺联合方案治疗晚期乳腺癌疗效较好 ,使用方便 ,毒性反应轻 ,是治疗晚期乳腺癌的较好方案。

Objective To evaluate the efficacy and safety of the oral combination chemotherapy of furtulon (FTL) and cyclophosphamide (CTX) for advanced breast cancer (ABC). Methods From Jun 2000 to Jun 2002, eighty three patients with ABC were treated with the two oral drugs as combined chemotherapy. The mean number of cycles was 5, median number of cycles was 6 (range 2～6). Results The overall response rate was 45.8%, The median time to progression was 6 months. The treatment was well tolerated, with related Grade 3 clinical adverse effect being only nausea and vomiting in 2 patients (2.4%) and mild hematologic toxicities. Conclusion Oral combined chemotherapy of FTL and CTX, being convenient and safe, is effective for patients with advanced breast cancer. [