兴奋毒性在肌萎缩侧索硬化的发病机制中具有重要作用

Excitotoxicity plays an important role in the pathologic progress of amyotrophic lateral sclerosis.

目的:分析比较肌萎缩侧索硬化病人和神经系统正常的受试者脑脊液中的谷氨酸水平,以明确由谷氨酸介导的“兴奋毒性”是否在ALS的发病机制中具有作用。方法:肌萎缩侧索硬化病人15例,神经系统正常的外科手术腰麻病人20例,采集脑脊液后用氨基酸自动分析仪进行检测。结果:肌萎缩侧索硬化病人脑脊液中谷氨酸水平与对照比较增高有极显著差异(两组分别为48.81±31.67μmol/L和15.85±6.70μmol/L)(P(0.01)。结论:由谷氨酸介导的“兴奋毒性”在肌萎缩侧索硬化的发病过程具有重要作用。

Objective: Compare the concentration of glutamate(Glu) in the cerebrospinal fluid(CSF) of patients with amyotrophic lateral sclerosis( ALS) and those with healthy nervous system to make definite the role of excitotoxicity mediated by Glu in the pathogenesis of ALS. Methods: Subjects were 15 patients with ALS and 20 neurologically normal patients who underwent lumbar anesthesia for surgery. Analyzed their CSF by amino acid measuring machine which utilized the principle of high performance liquid chromatography( HPLC). Results: The concentration of Glu was higher in patients with ALS (48. 81 ±31. 67μmol/L) than in controls (15. 85 ± 6. 70μmol/L) (P<0. 01). Conclusions: The excitotoxicity mediated by Glu plays an important role in the pathologic progress of ALS.