子宫内膜异位症的微血管密度改变——附55例报告

Changes of microvessel density in endometriosis

目的:探讨子宫内膜异位症的微血管密度(microvessel density,MVD)变化及其临床意义。方法:采用链菌素亲生物素-过氧化酶(strepavidin-peroxidase,S-P)免疫组织化学染色法检测55例卵巢子宫内膜异位症的病灶组织、10例子宫腺肌病、23例子宫肌瘤在位内膜中微血管,通过计算机进行微血管密度测定与比较。结果:卵巢子宫内膜异位症病灶的MVD为(160±53)条/平方毫米,子宫腺肌病在位内膜MVD(172±61)条/平方毫米,均显著高于子宫肌瘤在位子宫内膜的(129±45)条/平方毫米,具有统计学意义(分别为P<0.05,P<0.01),而卵巢子宫内膜异位症病灶与子宫腺肌病在位内膜比较差异无统计学意义。子宫内膜异位症病灶的分泌期与增殖期MVD比较差异无统计学意义;Ⅰ～Ⅱ期与Ⅲ～Ⅳ期子宫内膜异位症的MVD均存在血管增生,但两者差异比较无统计学意义。结论:子宫内膜异位症病灶中的MVD表达增高,并且与子宫腺肌病在位内膜的MVD无差异,提示MVD与子宫内膜异位症的发病有关。

Objective: To investigate the changes of microvessel density (MVD) in endometriosis and its clinical significance. Methods: Strepavidin-peroxidase immunohistochemical method was used to detect MVD in ectopic lesion in 55 cases of ovarian endometriosis, in eutopic endometrium in 10 cases of adenomyosis and 23 cases of myoma of uterus. Then the results of MVD were calculated and compared using computer system. Results: The MVD in ovarian ectopic lesion(160±53/mm^2) and endometrium of adenomyosis(172±61/mm^2) were both higher than that in endometrium(129±45/mm^2) of myoma of uterus. The difference was significant (P<0.05, P<0.01). But no difference was found between ovarian eutopic lesion and endometrium of edenomyosis(P>0.05). No difference was found between proliferation and secretory stage of menstrual cycle in ectopic endometrium. There was increased MVD in both Ⅰ～Ⅱ stage and Ⅲ～Ⅳ stage of endometriosis, but no difference was found. Conclusion: MVD is increased in lesions in endometriosis. There is no significant difference in MVD between endometrium of adenomyosis and endometriosis. This indicates MVD are involved in the pathology of endometriosis.