银屑病患者红细胞CR1基因组密度多态性的研究

Study on erythrocyte complementary receptor type 1 (CR1) genomic density polymorphism in patients with psoriasis

目的 : 探讨银屑病患者红细胞补体受体I型分子 (CR1)基因密度多态性与正常人之间的区别。方法 : 采用PCR技术加HindIII酶切检测银屑病患者红细胞CR1基因型。结果 : 银屑病患者红细胞CR1分子密度基因高表达者明显较正常人降低 ,而中表达和低表达者明显升高 (P <0 .0 1)。结论

Objective: To investigate the relationship between patients with psoriasis and normal subjects in RBC-CR1 genomic density polymorphism. Methods: Polymerase chain reaction (PCR) and Hind III restriction enzyme digestion were used to measure the genotype of erythrocyte complementary receptor type 1 (CR1). Results: The rate of high expression genotype was significantly lower, and the rate of medium expression and low expression genotype was remarkably higher in psoriatic patients than those in normal controls(P<0.01). Conclusion: The distribution of RBC-CR1 genomic density polymorphism may be related to the pathogenesis of psoriasis.