慢性荨麻疹患者甲状腺自身抗体测定及自体血清皮肤试验的意义

Detection of thyroid autoantibodies and autologous serum skin test in patients with chronic urticaria

目的 : 探讨慢性荨麻疹患者甲状腺自身抗体及自体血清皮肤试验的意义。方法 : 采用放射免疫法 ,对 6 0例慢性荨麻疹患者的甲状腺激素自身抗体及功能进行检测 ;对甲状腺自身抗体阳性的慢性荨麻疹患者进行自体血清皮肤试验。结果 : 6 0例慢性荨麻疹患者中甲状腺过氧化物酶抗体及促甲状腺受体自身抗体的阳性率分别为 2 1.7% (13 6 0 )和 15 % (9 6 0 ) ,均显著高于正常对照组 (P均 <0 .0 1)。 13例甲状腺自身抗体阳性的慢性荨麻疹患者自体血清皮肤试验 7例 (5 3.8% )阳性 ,显著高于自身抗体阴性对照组 (P <0 .0 1)。结论

Objective: To determine the level of thyroid autoantibodies and the autologous serum skin test in patients with chronic urticaria. Methods: Thyroid function tests, antithyroperoxidase antibodies (TPOAb) and TSH-receptor antibodies (TRAb) were measured respectively by radioimmunoassay in 60 patients with chronic urticaria, and the autologous serum skin test was performed in the patients with chronic urticaria with thyroid autoantibodies. Results: Thirteen of 60 patients with chronic urticaria 21.7% (13/60) were positive for TPOAb and 15% (9/60) for TRAb respectively. The positivity rates of TPOAb and TRAb in chronia urticaria were significantly higher than those in control subjects (P<0.01). Of the 13 patients with thyroid autoantibodies 7(53.8%) were positive in autologous serum skin test. There was significant difference between patients with autoantibodies and without autoantibodies (P<0.01). Conclusion: Thyroid autoantibodies and autologous serum skin test were important in diagnosis of autoimmune chronic urticaria.