贲门癌组织MVD与肿瘤淋巴结转移和患者预后的关系

Relationship of tumor micro-vessel density and lymph node metastasis and prognosis in human cardiac carcinoma

目的 :探讨贲门癌组织微血管密度与淋巴结转移和患者预后的关系。方法 :应用抗因子Ⅷ相关抗原抗体免疫组化SP法对 83例贲门癌组织中微血管密度 (MVD)进行检测、并研究其与淋巴结转移和患者预后的关系。结果 :高MVD组 (≥ 16 )较低MVD组 (<16 )更易发生淋巴结转移 (P <0 0 1) ,进行Kaplan Meier生存分析发现 ,MVD与患者生存情况有关 ,低MVD组的累积生存率明显高于高MVD组 (LogRank =14 4 )。 结论 :贲门癌组织微血管密度 (MVD)和淋巴结转移及患者预后有关 ,检测贲门癌组织MVD对判断患者预后有重要意义。

Objective:To study the role of tumor Micro-Vessel Density(MVD)in lymph node metastasis and prognosis of human gastric cardiac carcinoma.Methods:A total of 83 cardiac carcinoma samples were examined for MVD by immunohistochemical staining,then analyze the relationship of MVD and lymph node metastasis and prognosis of patients.Results:The tumor Micro-Vessel Density(MVD) were divided into low MVD group(<16)and high MVD group(≥16),MVD is higher(P<0.01) in samples with lymphaden metastasis than those in samples without lymphaden metastasis,and the high MVD group has a poor prognosis(LogRank=14.4).Conclusion:MVD in cardiac carcinoma is associated with tumor lymph node matastasis and patient′s prognosis,examination of tumor MVD can be utilized to predict the prognosis of patients with cardiac carcinoma.