冠心病患者血中过氧化脂质、超氧化物歧化酶变化及与中医证型关系的探讨

The Relationship Between the Changes of Blood LPO,SOD and Differential Diagnosis of TCM in Patients with Coronary Heart Disease

对57例冠心病患者及32名健康人的血中过氧化脂质(LP0)、超氧化物歧化酶(SOD)含量及活性水平的检测,并结合中医辨证分型进行探讨。结果表明:冠心病患者血中 LPO 含量明显增高,红细胞SOD 活性降低,SOD/LPO 比值缩小,其中以急性心肌梗塞(AMI)组最明显,其次为不稳定型心绞痛(UA)纽,稳定型心绞痛(SA)与正常对照组无显著性差异,提示 LPO 与 SOD 的变化与心肌受损的程度有密切关系。不同中医证型中以气虚证改变最为突出,痰浊证亦有较明显变化,血淤证的 LPO虽有一定增高,但其红细胞 SOD 活性无明显降低, 说明 LPO 含量与 SOD 活性水平的变化在冠心病中医辨证中,可以作为区别虚实不同证型的宏观指标之一。

The content and activity of blood LPO and SOD in 57 patients with coronary heart disease(CHD)and 32 health persons were determined and analyzed with differential diagnosis of TCM.The results showed that in patients with CHD,the content of blood LPO was much higher,activity of SOD was lower,and the LPO/ SOD ratio was lower,in which the patients with acute myocardiac infarction was very evident and the next was unstable angina pectoris,while stable angina pec- toris had no significant changes than that of the health control.It indicated that the changes of LPO and SOD were in close relationship with degree of myocardial damage,in which qi deficiency was the most serious and the next was stagnation of phlegm in the differentiation of symptoms and signs of TCM,although LPO of patients with blood stasis was increaised,the activity of SOD wasn't significant decreased.It suggested that the content and activity of LPO and SOD had emerged the different changes with the pathological development process of CHD,they might be one of material bases caused evolution of CHD from dificiency to excess type of TCM.