4-羟基-3,5-二甲氧基苯甲酰甘氨酸的合成研究

Stydy on Synthesis of 4-Hydroxy-3,5-dimethoxybenzoyl Hlycine

目的 合成 4 -羟基 - 3,5 -二甲氧基苯甲酰甘氨酸。方法 以丁香酸为起始原料 ,经乙氧羰基化、酰氯化、酰胺化、水解四步反应制得。结果 经波谱数据及元素分析认为合成的产物为目标产物。结论 所得化合物作为 N- (4 -羟基 - 3,5 -二甲氧基苯甲酰基 ) -甘氨酰正丁基胍的中间体 。

Objective To synthesize 4-hydroxy-3,5-dimethoxybenzoyl glycine.Methods It was prepared via syringic acid by the ethoxycarbonylation,acylation,amidation and hydrolysis.Results The product was target compound by the spectra analysis and elemental analysis.Conclusion The compound can be used to synthesize N-(4-hydroxy-3,5-dimethoxybenzoyl)-glycyl n-butyl guanidine,so the experiment needs improvement.