雷贝拉唑治疗100例消化性溃疡的临床观察

Clinical observation of rabeprazole for treating peptic ulcer in100cases

目的 :观察雷贝拉唑治疗消化性溃疡临床症状和抗H.pylori治疗方面的优势。方法 :选择100例近期胃镜下证实为消化性溃疡而且活检病理有H.pylori的病人随机分成两组 ,分别为雷贝拉唑组和奥美拉唑组 ,三联疗法一周 ,停药后一月及三月复查14C呼气试验。结果 :雷贝拉唑组的12小时、24小时、72小时的临床症状缓解率高于奥美拉唑组 ,差异有显著性(P<0.05)。一周抗H.pylori治疗 ,雷贝拉唑的H.pylori根除率与奥美拉唑组相比 ,差异无显著性 (P>0.05)。结论 :雷贝拉唑在快速缓解消化性溃疡症状优于奥美拉唑。而在一周抗H.pylori治疗两组无差异。

Objective:To observe the superiority of rabeprazole for relieving the clinical symptom of peptic ulcer and resisting helicobacter pylori.Methods:100cases were confirmed to be peptic ulcer by gastroscopy in recently,also were confirmed to be affected by helicobacter pylori under pathological examination,those cases were divided into two groups randomly,namely rabeprazole group and omeprazole group.The triple therapy was done for a week,14C-expiratory test was detected in1.3months after cessation of administration.Results:The palliation rate of clinical symptom in12,24,72hours after treatment in rabeprazole group was higher than that in omeprazole group,with significant difference(P<0.05).but the difference of eradication rate in one week after treatment of anti-helicobacter pylori was not significant between them(P>0.05).Conclusion:Rabeprazole is superior to the omeprazole in relieving the symptom of peptic ulcer,but the difference in one week after treatˉment of anti-helicobacter pylori is not significant between both groups.