摘要
目的 探讨E 钙粘着蛋白 (E cad)在鳞状细胞癌 (SCC)、基底细胞癌 (BCC)、Bowen病、日光角化病 (AK)、角化棘皮瘤 (KA)、脂溢性角化病 (SK)中的表达与肿瘤分化程度、侵袭转移等生物学行为的关系。方法 用免疫组化染色方法检测 12 9例不同表皮肿瘤E cad的表达。结果 E cad在BCC ,SK ,KA表皮中的表达与正常表皮相似 ,为表皮全层细胞间较强的染色 ,而在SCC中表达显著减弱或完全无表达 ,在AK和Bowen病表皮正常区域表达正常或下调 ,但在细胞间变区域无染色。结论 E cad在恶性皮肤癌中表达下调 ,可能与表皮肿瘤的侵袭和转移有关。
Objective To evaluate the relationship between E-cadherin and epidermal tumors.Methods We investigated the expression of E-cadherin in 129 cases of human epidermal tumors including basal cell carcinoma(BCC),squamous cell carcinoma(SCC),Bowen disease,actinic keratosis(AK),keratoacanthoma(KA),and seborrhoeic keratosis(SK).By immunohistochemical staining using a monoclonal antibody specific for E-cadherin.Results Similar to the E-cadherin expressed in normal epidermis,E-cadherin was strongly expressed in cell of samples BCC,SK,and KA,whereas marked decrease or lose of E-cadherin expression was found in the cells of SCC.Compared with the normal epidermal cells the expression of E-cadherin in AK and Bowen disease was normal or reduced,with complete absence of staining in dysplasis arease.Conclusion Considering the clinical and histological features of these tumors,the reduction of E-cadherin expression is considered to be associated with the invasion and metastasis of human epidermal tumors.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2004年第3期129-131,共3页
The Chinese Journal of Dermatovenereology
基金
华邦皮肤科学教育和研究基金
