合并系统性红斑狼疮的尖锐湿疣患者细胞免疫功能检测

Detection of Cellular Immune Function in Condyloma Acuminatum Patients with Systemic Lupus Erythematosus

目的 研究合并系统性红斑狼疮 (SLE)的尖锐湿疣 (CA)患者细胞免疫功能状态。方法 运用流式细胞术 ,分析了 2 1例合并SLE的CA患者的外周血中T淋巴细胞免疫表型的特点。同时用ELISA法测定了血清中白介素 2(IL 2 )和白介素 12 (IL 12 )的水平变化。结果 2 1例合并SLE的CA患者外周血中总T(CD3 + ) ,Th(CD4+ )细胞及Th/Ts(CD4+ /CD8+ )均低于正常对照组和单纯CA患者对照组 (P <0 .0 1或P <0 .0 5 ) ,而Ts(CD8+ )的比例显著高于正常对照组和单纯CA患者对照组 (P <0 .0 1)。 2 1例合并SLE的CA患者血清中IL 2和IL 12水平均低于正常对照组和单纯CA患者对照组 (P <0 .0 1)。结论 合并SLE的CA患者的细胞免疫功能受到不同程度的损害 ,并且较单纯CA患者的细胞免疫功能受到更严重的损害。

Objective To study the cellular immune function in condyloma acuminatum patients with systemic lupus erythematosus.Methods Using flow cytometry,detected the characteristic of peripheral blood lymphocyte of 21 cases of condyloma acuminatum with systemic lupus erythematosus.Meanwhile,the serum level of IL-2 and IL-12 of the patients was detected by ELISA.Results The results showed that the percentages of pan T,Th cells,the ratio of Th/Ts and the serum level of IL-2 and IL-12 were lower( P <0.01 or P <0.05) than those of controls.While,the percentages of Ts cells was significantly higher( P <0.01) than those of controls.Conclusion It indicates that the cellular immunity in condyloma acuminatum patients with systemic lupus erythematosus has been damaged more or less.The cellular immunity was more severely damaged than that of the patients with condyloma acuminatum.