“泻剂结肠”大鼠结肠肌电活动及其对乙酰胆碱反应的变化

The changes of electrophysiology of the rat with cathartic colon and reaction to acetylcholine

目的 探讨慢传输型便秘 (Slowtransitconstipation ,STC)的发生机制。方法 建立大鼠“泻剂结肠”模型 ,测定大鼠结肠肌电生理活动及其对乙酰胆碱 (Ach)的反应变化。结果 “泻剂结肠”大鼠结肠慢波的频率减慢与振幅降低 ;结肠对Ach的反应性明显减弱。结论 长期服用接触性泻剂 ,对结肠ENS有损害作用 。

Objective To explore the etiopathology of slow transit constipation(STC). Methods The model of rat with cathartic colon was established and the changes of colonic electromyography and reaction to acetylcholine(Ach) were examined. Result The frequency, amplitude of slow wave and colon reaction to Ach of rats with cathartic colon decreased markedly. Conclusion Long term abuse of stimulant laxatives could damage enteric nervous system(ENS) and accelerate the pathological changes of STC.