晚发性维生素K缺乏症伴颅内出血50例临床分析

Clinical analysis of late-genetic vitamin K deficiency with intracranial hemorrhage in50cases

目的 :探讨晚发性维生素K缺乏症伴颅内出血的病因和防治。方法 :对1991年1月～2003年12月收治的晚发性维生素K缺乏症伴颅内出血50例患儿进行临床分析。结果 :单纯母乳喂养45例 ,占90 % ;农村与城镇之比为12 :1 ;病前有腹泻36例 ,占72 % ;使用过抗生素38例 ,占76 %。治疗上使用维生素止血的同时予输血、甘露醇脱水及对症处理 ,治愈30例 ,自动出院6例 ,转脑外科14例 ,治愈率达60 %。结论 :本病发病以农村和单纯母乳喂养为多 ,病前有腹泻和使用过抗生素可诱发。加强农村卫生知识宣传及用维生素K预防出血至关重要。治疗上使用维生素K止血的同时予输血及对症处理 ,预后好。

Objective:To study the cause and prophylactic-o-therapeutic means of late-genetic vitamin K deficiency with intracranial hemorrhage.Methods:50sick infants of late-genetic vitamin K deficiency with intracranial hemorrhage from January1991to December2003in our hospital were analyzed clinically.Results:Among this group,45cases(90%)were simple breast feeding,the ratio of country/town was12:1;36cases(72%)had diarrhoea before this disease;38cases(76%)had been used with antibiotics.In the treatment,the vitamin K was given,the blood transfusion,mannitol dehydration and heteropathy were also given at the same time.30cases were cured.6cases were discharged automat-icly.14cases were transfered to thoracic surgery department.The cure rate was60%.Conclusion:Late-genetic vitamink deficiency with in-tracranial hemorrhage is very common in the infants of countryside and simple breast feeding,which may be provoked by both diarrhoea and using antibiotics before this disease.Strengthening propaganda in counntryside and using vitamin K are very important in preventing hemorrhage.In the treatment,the vitamin K is used,the blood transfusion and heteropathy are given at the same time,and the prognosis is good.