桂山厚丛柳珊瑚化学成分的研究(二)

FURTHER CHEMICAL STUDIES ON THE GORGONIAN HICKSONELLA GUISHANENSIS ZOU FROM EAST CHINA SEA

对采自中国东海的桂山厚丛柳珊瑚HicksonellaguishanensisZou的化学成分进行研究 ,从中分离得到了 5个化合物 ,利用波谱技术分析和文献对照 ,确定其结构分别鉴定为 (1R ,2E ,4E ,7E ,11E) 新松烯 2 ,4 ,7,11 四烯 (1)、(1R ,4R ,2E ,7E ,11E) 新松烯 2 ,7,11 三烯 4 醇 (2 )、正十八醛 (3)、邻苯二甲酸酐 (4 )和α 乙基葡萄糖 (5 )。在活性测试中 ,化合物 1～ 2对COX 2显示弱的抑制活性。

Four known compounds were isolated from the gorgonian coral Hicksonella guishanensis Zou collected from East China sea. Their chemical structures were identified by spectroscopic analysis and by comparison with the data reported in literature as(1R,2E,4E,7E,11E)-cembra-2,4,7,11-tetraen (1),(1R,4R,2E,7E,11E)-cembra-2,7,11-trien-4-ol (2),octadecanal(3),ο-phthalic anhydride(4)and α-ethyl glucoside (5),respectively.Compounds 1～2 showed weak inhibitory activity to COX-2 in bioassay.