胰腺浆液性微囊性囊腺瘤1例报道并文献复习

Serous microcystic cystadenoma of pancreas: a case report and review of literature

目的 探讨胰腺浆液性微囊性囊腺瘤的临床病理学特征及诊断、鉴别诊断要点。方法 对 1例胰腺浆液性微囊性囊腺瘤进行临床病理分析及免疫组化研究。结果 胰腺浆液性微囊性囊腺瘤临床上可以表现为消瘦、乏力而体格检查阴性 ;镜下肿瘤由大小不等的囊腔组成 ,囊壁内衬单层立方上皮 ,胞质清亮 ,核小而圆、居中 ,核分裂象极少见 ,细胞无异型性 ,囊腔之间可见粗大的纤维结缔组织分隔。免疫组化瘤细胞keratin和EMA (+ ) ,S 10 0、vi mentin、actin、CGA、Syn、CEA、desmin和Ⅷ因子 (-)。结论 胰腺浆液性微囊性囊腺瘤是一种罕见肿瘤 ,其诊断和鉴别诊断主要依靠病理组织学和免疫组化 ,部分肿瘤的良恶性很难确定 。

ObjectiveTo explore the clinicopathologic features and differential diagnosis of serous microcystic cystadenoma of the pancreas MethodsA case of serous microcystic cystadenoma of the pancreas was studied with conven tional histopathological and immunohistochemical stains ResultsThe clinical symptoms of serous microcystic cystadenoma of the pancreas were wei ght loss and no other positive physical examination findings Histopathology show n neoplasm composed of numerous small cysts lined by uniform glycogen-rich cuboidal epi thelial cells, disposed around a central stellate scar Immunohistochemical stai n shown positive for keratin and EMA, negative for S-100, vimentin, actin, CGA, S yn, CEA, desmin and VIII factor ConclusionsSerous microcystic cystadenoma is a rare neoplasm. The diagnosis of serous micro cystic cystadenoma mainly relies on histopathological and Immunohistochemical findings