期刊文献+

survivin在胃癌组织中的表达及临床意义 被引量:4

Expression of survivin in human gastric carcinoma and its clinical significance
下载PDF
导出
摘要 目的 探讨survivin在胃癌诊断、预后等方面的意义。方法 利用RT PCR技术检测 3 8例胃癌组织标本和3 8例相应癌旁组织标本中survivinmRNA表达情况。结果  3 8例胃癌组织标本中有 2 0例survivin基因表达阳性 ,高、中、低分化胃腺癌的阳性表达率分别为 0 %、45 5%和 60 % ;发生淋巴结及远处转移的胃癌组织标本中 72 %表达survivin ,明显高于无转移组。 3 8例癌旁组织标本均无该基因的阳性表达。结论 survivin在胃癌组织中有较高的表达率 ,且表达具有高度肿瘤特异性 ; ObjectiveTo investigate the expression of survivin in human gastric carcinomas and to explore the clinical significance of survivin in d iagnosis or prognosis of gastric carcinoma MethodsExpression of survivin in 38 cases of human gastric carcinomas and 38 corresponding normal tissue specimens were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) ResultsIn the 38 gastric carcinomas studied, survivin mRNA was detected in 20 cases (52 6%) The positive rate of survivin expression in cases of lymphoid metastasis was h igher than that without lymphoid metastasis (P=0 001, <0 01) ConclusionsSurvivin is expressed in a high percentage of gastric carci nomas and associated with clinical grade and prognosis of gastric carcinoma
出处 《诊断病理学杂志》 CSCD 2004年第1期38-39,共2页 Chinese Journal of Diagnostic Pathology
关键词 SURVIVIN 胃癌 表达 癌组织 聚合酶链反应 Survivin Stomach neoplasm Polymerase chain reaction
  • 相关文献

参考文献8

  • 1Adida C,Crotty PL,McGrath J,et al.Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation[J].Am J Pathol,1998,152(1):43-49.
  • 2Ambrosini G,Adida C,Sirugo G,et al.Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting[J].J Biol Chem,1998,273(18):11177-11182.
  • 3Tanaka K,Iwamoto S,Gon G,et al.Expression of survivin and its relationship to loss of apoptosis in breast carcinomas[J].Clin Cancer Res,2000,6(1):127-134.
  • 4Ito T,Shiraki K,Sugimoto K,et al.Survivin promotes cell proliferation in human hepatocelluar carcinoma[J]. Hepatology,2000,31(5):1080-1085.
  • 5Lu CD,Altieri DC,Tanigawa N.Expression of a novel antiapoptosis gene,survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas[J].Cancer Res,1998,58(9):1808-1812.
  • 6Shin S,Sung BJ,Cho YS,et al.An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and-7[J].Biochemistry,2001,40(4):1117-1123.
  • 7Andrade F,Roy S,Nicholson D,et al.Granzyme B directly and efficiently cleaves several downstream caspase substrates:implications for CTL-induced apoptosis[J].Immunity,1998,8(4):451-460.
  • 8Sarela AI,Macadam RC,Farmery SM,et al.Expressin of the antiapoptosis gene,survivin,predicts death from recurrent colorectal carcinoma[J].Gut,2000,46(5):645-650.

同被引文献20

引证文献4

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部