摘要
目的 : 探讨银屑病患者外周血中转化生长因子 - β1(TGF - β1)及表皮生长因子 (EGF)在银屑病发病中的意义。方法 : 采用ELISA方法对 37例寻常型银屑病患者外周血中TGF - β1及EGF的水平进行检测。结果 : 银屑病患者及正常人外周血中TGF - β1的平均血清浓度为 18.4 8± 3.13(ng ml)及 18.0 1±3.2 1(ng ml) ,两者之间的差异统计学上无显著性意义 (P >0 .0 5 ) ;EGF的血清浓度分别为 2 4 .72± 11.4 8(ng ml)及 18.11± 2 .19(ng ml) ,两者之间的差异在统计学上有显著性意义 (P <0 .0 5 )。结论
Objective: To evaluate the roles of transforming growth factor-β1 (TGF-β1) and epidermal growth factor (EGF) in pathogenesis of psoriasis.Methods: The serum levels of TGF-β1 and EGF were measured by double antibody sandwich enzyme-linked immunosorbent assay in 37 patients with psoriasis and in 23 normal controls. Results: There was no statistical difference in the serum level of TGF-β1 between psoriasis patients and normal controls (P>0.05). The EGF level was significantly higher in psoriasis patients than that in normal controls (P<0.05). Conclusion:The EGF may play a role in the pathogenesis of psoriasis.
出处
《中国麻风皮肤病杂志》
北大核心
2004年第2期120-121,共2页
China Journal of Leprosy and Skin Diseases
