胃十二指肠疾病血、尿PGE_2和PGF_(2α)含量及其与中医证型的关系

Relations between Syndrome-typing in TCM and the Levels of PGE_2 and PGF_(2α) in Blood and Urine in Diseases of Stomach and Duodenum

本文在过去工作的基础上对脾虚证与PG的关系作了探索,发现脾虚证病人血中PGE_2水平明显升高,PGF_(2α)。明显降低。尿中PGE_2水平和PGE_2/PGF_(2α)比值明显升高。本文还观察了健脾益气糖浆对脾气虚证病人,气滞胃病冲剂对肝胃不和病人的疗效,发现治疗前后血中PGE_2和PGF_(2α)水平均无明显变化。比较临床脾虚证病人和实验性脾虚大鼠血中PG水平,发现PGF_(2α)含量两者均下降,脾虚病人PGE_2升高,脾虚大鼠PGE_2下降,昆明两者同中有异,符合对中医动物模证的评价。

In patients of deficient spleen, the blood PGE_2 is markedly elevated, whereas PGF_(2α), markedly lowered. That of urine PGE_2 and PGE_2/PGF_(2α)markedly increased. In deficient spleen treated with'Jianpi Yiqi'(Spleenstrenthening and Oi-benefit)Syrup and Disharmony of Liver and Stomach treated with'Qizhi Weiteng'(Stagnant Qi and Stomachache)Powder, there were no obvious changes in PGE_2 and PGF_(2α)before and after treatment. Comparison of the PG contents between patients of deficient Spleen and experi mental deficient Spleen rats revealed PGF_(2α), lowering in both groups, while FGE_2 increased in patients and lowered in rats, suggesting that there are differences as well as similarities in both grou(?)s, and this corresponds to the TCM assessment of animal models.