慢性肝病患者血清肝纤维化指标联合γ-球蛋白检测的意义

The Significance of Monitoring Sera Hepatic Fibrosis Markers & γ-Globulin of Patients with Chronic Hepatitis

目的 探讨各型慢性肝病患者血清肝纤维化指标及γ-球蛋白与肝纤维化的关系。方法 选择各型慢性肝病患者,检测患者血清透明质酸(HA)、层粘蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、γ-球蛋白进行分析。结果 HA、PCⅢ在慢肝中度时明显升高; LN、Ⅳ-C和γ-球蛋白在慢肝重度时明显升高。结论 HA、PCⅢ适用于肝纤维化早期诊断;LN、Ⅳ-C、γ-球蛋白适用于肝纤维化中晚期诊断。

Objective To research on the relations between sera hepatic fibrosis markers, γ-globulin and liver fibrosis of all types patients with chronic hepatitis. Methods Choosing all typespatients with chronic hepatitis, examining and analyzing hyaluronic acid (HA), laminar(LN), procollagentype III (PCIII), type IV collagen (IV-C) andγ-globulin. Results HA and PCIII significantly risesin moderate chronic hepatitis; LN, IV-C and γ-globulin significantly rises in severe chronic hepatitis.Conclusion HA and PCIII are applied in early liver fibrosis diagnosis. LN, IV-C, γ-globulin areapplied in advanced liver fibrosis diagnosis.