慢性肝炎肝组织病理改变与血清总胆汁酸关系探讨

Correlation between serum total bile acid level and hepatic activity index and hepatic fibrosis in patients with chrohic hepatitis

目的 研究空腹血清总胆汁酸 (TBA)与血清纤维化指标的关系 ,阐明其临床意义。方法 收集慢性肝病患者 73例 ,肝组织活检当天行血清TBA及HA检测 ,并分析其相关性。结果 慢性肝炎患者TBA水平与正常值相比明显升高 ,与肝组织炎症活动 (G)、纤维化程度 (S)及血清纤维化指标 (HA)呈正相关 ,相关系数r分别为 0 .5 15、0 .43 0、0 .687。

Objective To study the correlation between serum total bile acid (TBA) level and the liver injuries.Methods In 73 patients,TBA and HA were detected by automatic biochemistry analyzer and RIA.The liver biopsies were performed.Results The level of serum TBA in patients with chronic hepatitis significantly increased compared with normal control.From G 1 to G 4,and from S 0-1 to S 4,the level of TBA elevated.There was a significantly positive correlation between TBA level and liver inflammation as well as fibrosis.Conclusion TBA is one of the sensitive marker reflecting liver inflammation and fibrosis,which is similar to HA for liver fibrosis markers.