经口明视下阿霉素治疗复发性三叉神经痛的临床观察

EFFECTS ON RECURRENT PRIMARY TRIGEMINAL NEURAGIA FOLLOWING ADRIAMYCIN INTRAORAL INJECTION IN TO THE NERVE

目的 :探讨经口明视下阿霉素治疗复发性三叉神经痛 (第Ⅱ、Ⅲ支 )的疗效。方法 :选择复发性三叉神经痛 (第Ⅱ、Ⅲ支 )患者 4 0例 ,全部患者均接受过无水酒精注射治疗或开颅手术。局麻监护下 ,经口内解剖 ,分离出三叉神经第Ⅱ、Ⅲ支 ,微量注射器直视下注入阿霉素 3mg。结果 :39例患者术后 1周内三叉神经痛症状不同程度减轻 ,其中 72 .5 % (2 9/4 0 )在术后 2 4h内疼痛减轻 ,2 5 %(10 /4 0 )在术后 1周内疼痛减轻 ,无效 2 .5 % (1/4 0 )。术后 2年内有 3例复发 ,复发率为 7.5 % (3/4 0 ) ,复发患者症状均较前减轻 ,发作次数及持续时间均较前减少。结论 :经口明视下阿霉素治疗复发性三叉神经痛是一种安全、有效的方法。

Objective: To explore the effects of intraoral injection of adriamycin on recurrent primary trigeminal neuralgia(Ⅱ?Ⅲ). Methods: Forty patients of recurrent primary trigeminal neuralgia(Ⅱ?Ⅲ)underwent stomatology operation. Adriamycin 0.3ml was injected into nerve trunk directly. Results: Twenty-nine patients (72.5%)felt pain relieve in one day, ten (25%) felt pain relieve in one week, one (2.5%) failed. Three cases recurred in two years,yet the pain was relatively moderate. Conclusion: Recurrent primary trigeminal neuralgia(Ⅱ?Ⅲ)following the treatment of nerve being injected with adriamycin is effective and safe.