芬太尼透皮贴剂治疗带状疱疹及疱疹后神经痛的疗效观察

THE EFFECTIVENESS OF TRANSDERMAL FENTANYL FOR PAIN CONTROL OF HERPES ZOSTER AND POSTHERPETIC NEURALGIA

目的 :观察芬太尼透皮贴剂 (多瑞吉 )对带状疱疹及疱疹后神经痛的疗效 ,本文选择了 31例不宜行神经阻滞的病人作为研究对象。方法 :31例病人在抗病毒治疗的同时均使用 2 5 μg/h的多瑞吉作为首次量 ,如疼痛控制不满意 ,临时追加曲马多缓释片 ,下次换贴时再增加至 5 0 μg/h ,观察其对患者疼痛的缓解程度、生活质量的改善以及出现的并发症。结果 :31例病人经多瑞吉治疗后 ,2例因副反应而终止治疗 ,其余患者疼痛明显缓解 ,VAS评分从 8.5 1± 1.12降至 2 .4 7± 1.2 3,生活质量明显提高 ,部分并发症随时间延长而减少。结论 :多瑞吉能有效地控制带状疱疹及疱疹后神经痛 ,改善病人的生活质量 ,随着病人对多瑞吉的适应 ,部分并发症逐渐减少。

Objective: To observe the therapeutic effect of transdermal fentanyl (Duragesic) in patients with Herpes Zoster and Postherpetic Neuralgia. Methods: Thirty-one patients were treated with transdermal fentanyl initially in the lowest available delivery rate (25μg/h). A higher dose( 50μg/h) was given only when the pain of patients was not controlled well. Tramadol was present temporarily before changing transdermal fentanyl patch. The analgesic effect, the quality of life, and the side effects were observed. Results: Two patients stopped the fentanyl treatment because of adverse events. Duragesic decreased the pain scores of VAS significantly from 8.51±1.12 to 2.47±1.23 for the patients with herpes zoster and postherpetic neuralgia. The quality of life was improved and some complications became less after Duragesic treatment.Conclusion: Transdermal fentanyl could provide excellent pain relief and the quality of life for the patients with herpes zoster and postherpetic neuralgia. Some complications could reduce along with Duragesic treatment.