涎腺基底细胞腺瘤和腺样囊性癌的AgNORs定量分析

QUANTITATIVE ANALYSIS OF AgNOR COUNTS OF BASAL CELL ADENOMA AND ADENOID CYSTIC CARCINOMA

本文应用Howell银胶染色法对39例病检资料(其中BCA 14例、ACC22例、正常涎腺3例)进行AgNORs定量分析。实验结果表明:ACC组细胞内AgNORs较多,平均每个细胞为2.68±0.7,个别可多达6～8;BCA组平均每个细胞为1.34±0.098,个别3～4;正常涎腺导管和腺泡细胞平均为1.23±0.04,个别亦为3～4。后两者与前者间的差异在统计学上有显著性意义(P<0.01)。因此,我们认为应用银胶染色法进行AgNORs定量分析有助于区分BCA和ACC,有一定的实用意义。另对本组22例ACC按其组织学类型进行AgNORs定量分析,发现14例分化较好的筛状型和管状型ACC的AgNORs数明显低于8例分化较差的实体型和混合型ACC,两者在统计学上有显著性差异(P<0.01)。

Quantitative analysis of AgNOR counts of 39 cases (14 basal cell adenoma BCAand 22 adenoid cystic carcinoma ACO of salivary glands and 3 normal controls) werereported. Results showed significant differences of AgNOR counts between adenoidcystic carcinoma and basal cell adenoma or normal salivary glands (P<0 .01). Inaddition, the AgNOR counts in different histologic type of 22 adenoid cystic carci-noma were analyzed. The differences between cribriform, tubular type and solid,mixed type were also shown (P<0.01). These differences suggest that AgNOR stain-ing.technique is helpful to distinguish between BCA and ACC and also to classifythe degree of malignancy of ACC.