上海市552例女性乳腺癌流行因素研究

A CASE-CONTROL STUDY FOR BREAST CANCER OF WOMEN IN SHANGHAI

本研究对上海市1988年1月～1989年6月诊断的女性乳腺癌患者进行调查,以1:1配对,年龄17～75岁。共调查118项食品和64项非膳食因素。发现月经初潮年龄提前、被动吸烟、乳腺癌家族史、曾有精神创伤及曾患乳腺纤维瘤、乳腺组织增生、胆结石、由于疾病而停经和乳腺炎者,均与乳腺癌的发生有联系,但与乳腺炎联系较弱。若长期参加锻炼或经常食用大豆制品者和服用蜂皇浆者,对预防乳腺癌有效。

A case-control study of 552 cases of breast cancer has been conducted in urbanShanghai. These cases were newly histologically diagnosed in large hospitals inShanghai between Jan. 1, 1988 to June, 30, 1989. Interviews were conducted at the homeof the subjects. The questionnaire included 118 food items and 64 items of nondietaryfactors. Total caloric, fat, protein, saturated fatty acid, and linolein intake showedno association with breast cancer. We found early age at menarche, passive smoking,family history of breast cancer,mental upset significantly increased the risk for breast cancer, especially, the mental upset and family history of breast cancer RR=4.31(95% CI 1.89-9.84), RR=7.75 (95% CI 4.38-13.71) respectively, Mast-fibro-adenoma, mastadenitis, cholelithiasis, and cause of disease for menopause showed anincreased risk for breast cancer, these estimated relative risks were RR=6.53 (95%CI 2.22-19.2), RR=3.03 (95% CI 1.65-5.58), RR=2.5(95% CI 1.09-5.70), RR=2.05(95% CI 1.16-3.64), RR=1.39 (95% CI 1.12-1.72), respectively. Taking oral contra-ceptive Ⅰand ginseng for a long time could increase the risk of breast cancer, RR=2.13 (95% CI 1.19-3.81), RR=1.51 (95% CI 1.12-2.04), respectively. But takingroyal jelly long time seems to protect and against breast cancer. There was atendency that women enjoy exercises would protect aginst breast cancer.