35例耐药绒毛膜癌的治疗

COMBINATION THERAPY OF DRUG-RESISTANT CHORIOCARCINOMA

自1983年1月～1990年6月共收治外院转来的耐药绒癌35例。全组病例中有88.6％病例已在外院应用5个以上化疗疗程,并证实对3种以上抗绒癌药物耐药。治疗方法采用PBA或PVBA化疗方案为主配合放疗或手术。随访结果PBA组1、2、3年治愈率均为60％,PVBA组1、2年治愈率分别为73.3％和75％。分析表明耐药种类越多,以前用药疗程越多,预后越差。作者认为PVBA方案是治疗耐药绒癌的良好方法。

From Jan. 1983 to June 1990, 35 drug-resistant choriocarcinoma treated in otherhospitals were referred to our hospital. Among them, 88.6% of patients had alreadyundergone more than 5 courses of chemotherapy, and the tumor showed resistance toat least 3 anti-choriocarcinoma drugs. PBA or PVBA chemotherapy as the main treat-ment was combined with irradiation or surgery. The 1,2,and 2-year survival rates ofPBA group were 60%, while 1-and 2-year Survival rates of PVBA group were 73.3%and 75% respectively. The more the varieties of resistant drugs and the more thecourses of previous chemotherapy had undergone, the worse the prognosis would be.The authors believe that the PVBA chemotherapy is very effective for drug-resistantchoriocarcinoma.