胃癌、不典型增生和正常人血清中视黄醇、α-生育酚、β-胡萝卜素和12种元素的研究

SERUM LEVELS OF RETINOL,α-TOCOPHEROL,β-CAROTENE AND 12 ELEMENTS IN GASTRIC DYSPLASIA AND GASTRIC CANCER PATIENTS

本文测定了45例胃癌、41例胃不典型增生(胃癌癌前病变)和48例对照组血清中视黄醇、α-生育酚、β-胡萝卜素和12种元素(Zn、Cu、Mn、Fe、Ca、Mg、Ni、Cr、Co、Cd、Mo、Se)的含量。结果表明:胃癌病人血清中的β-胡萝卜素和硒、钴含量低于胃不典型增生病人,更低于对照组。此外,胃癌组与胃不典型增生组比较,明显降低的元素有镍、铬;明显升高的元素有锰、钙、镉。胃癌组与对照组比较明显降低的有锌、铁、铬、镉;明显升高的有锰、钙、镁、钼。胃不典型增生组与对照组比较,明显下降的有锰、铁、镉;明显升高的有钼。上述15个指标,经逐步回归判别分析,筛选出10个变量指标(Mn、Fe、Ca、Cr、Mo、Co、Cd、Se、α-生育酚、β-胡萝卜素)用以识别胃癌,其识别符合率为100％。若用逐步回归判别分析,判别血清中Mn、Cr、Mo、Co、Cd五个微量元素的含量,其识别胃癌的符合率亦为97.8％。作者认为对患者血清中微量元素进行逐步回归判别可作为胃癌诊断的参考指标,并认为适当补充硒和β-胡萝卜素将有助于预防胃癌。

Serum levels of retinol, α-tocopherol, β-carotene and 12 elements (Zn, Cu, Mn,Ca, Mg, Cr, Co, Cd, Mo, Se)were determined in 45 gastric cancer and 41 gastric dysplasiapatients, and 48 normal subjects. The results showed that β-carotene and Se、Co werelower in gastric cancer patients than that in gastric dysplasia patients or in normalsobjects. Ni and Cr levels were lower and Mn, Ca and Cd were higher in gastric cancerthan in dysplasia patients. Zn, Fe, Cr, Cd were lower and Mn, Ca, Mg, Mo levelswere higher in gastric cancer patients than in normal. The differences mentioned arestatistically significant. The stepwise discriminant analysis of 10 variables (Mn, Fe,Ca, Cr, Mo, Co, Cd, Se, α-tocopherol, β-carotene) had been used in identifyinggastric cancer, the positive rate being 100%. The potential protective effect of β-carotene and Se against gastric cancer is an interesting postulate. We suggested thatoptimum supplement of β-carotene and Se might be beneficial to gastric dysplasia