高血压病颈动脉壁结构改变及其与动脉扩张性的关系

Relationship between structural changes of intima-media and distensibility of the carotid in primary hypertension

目的 应用背向散射积分技术观察高血压病患者颈动脉内膜中层结构改变及其与动脉扩张性改变之间的关系。方法 比较 43例高血压病患者与 2 5例健康志愿者颈动脉内膜中层校正背向散射积分 (CIBS)、IBS周期变异 (CVIB)、内膜中层厚度 (IMT)及颈动脉扩张性 (CD)的改变 ,并分析CIBS、CVIB与CD、IMT等参数之间的关系。结果 高血压病组CIBS、IMT显著高于对照组 ,而CD显著低于对照组 ;高血压病组CIBS与CD显著负相关而与IMT呈正相关 ,多因素逐步回归证实CD、IMT依次进入以CIBS为因变量的回归方程。结论 高血压病患者颈动脉壁内膜中层背向散射积分参数明显高于正常人 ,提示高血压病早期即有动脉壁结构改变 。

ObjectiveTo explore the wall structural ch anges of the carotid with integrated backscatter and their effects on wall distensibility in patients with primary hypertension. MethodsForty-three patients with primary hypertension and 25 normal subjects were enrolled in the study. The corrected integrated backscatter (CIBS) and its cyclic variability (CVIB), the thickness of intima-media (IMT) and the carotid distensibility (CD) were compared between hypertensive group and normal control group. ResultsCIBS and IMT were increased while CD was decreased more significantly in hypertensive patients than in normal subjects. Demonstrated a negative correlation with CD but a positire correlation with IMT in hypertensive patients. ConclusionsThe wall structural changes of the carotid are closely correlated with the functional disorder in patients with primary hypertension.