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环氧化物水解酶基因多态与疾病遗传易感性研究进展 被引量：4

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摘要 环氧化物水解酶(epoxide hydrolase,EH)是参与外源性化学物质体内生物转化第二时相反应的一种重要代谢酶.编码该酶的基因在进化过程中会出现一定程度的变异,即基因多态,使其在代谢过程中的作用发生相应改变.EH基因多态导致个体对环境中毒物或致癌物的易感性不同,从而发生疾病的危险性亦不同.关于EH基因多态与疾病易感性的关系,国内外已经有不少报道,现综述如下.
作者 曹燕燕 边建超
机构地区 复旦大学公共卫生学院流行病学教研室
出处 《中华流行病学杂志》 CAS CSCD 北大核心 2004年第4期355-358,共4页 Chinese Journal of Epidemiology
基金 国家自然科学基金(39870654)
关键词 环氧化物 水解酶基因 多态性 疾病遗传 易感性
分类号 R394 [医药卫生—医学遗传学]
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参考文献40

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二级参考文献11

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共引文献25

同被引文献45

引证文献4

二级引证文献7

中华流行病学杂志
2004年 第4期

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