某汉族脐带血DNA库父母籍贯及姓氏构成的分析

Survey on Native Place and Surname of Parents in a Newborn Infant Cord Blood DNA Bank of Han Nation

为了评价以医院为单位整群抽样获取的脐带血DNA库与一般人群的相似性 ,对北京某医院收集的脐带血DNA库提供者父母籍贯和姓氏分布进行统计分析。以该医院产科连续出生的 5 6 6名汉族新生儿及其父母为研究对象 ,收集产妇及其丈夫的姓名、籍贯等资料 ,分析新生儿父母籍贯和姓氏的分布与构成 ,并与全国和北方汉族人群姓氏构成频率和构成顺位进行比较。DNA库中父母籍贯北京的占 4 5 1%～ 4 9 8% ,河北、山东、河南、江苏的比例较高 (3 7%～ 10 6 % ) ,父母籍贯覆盖全国 30个省、市、自治区 (除西藏、贵州 ) ,但多数地区所占的频率较低。父亲姓氏 14 6个、母亲姓氏 14 5个 ,其中构成比大于 1 5 %的姓氏有 9个。父亲姓氏前 8位为 :王 (9 0 % )、李 (8 0 % )、张 (7 8 % )、刘 (7 1% )、杨 (4 1% )、陈 (3 5 % )、赵 (3 4 % )、高 (1 6 % ) ,母亲姓氏前 8位为 :王 (11 8% )、李 (8 3% )、张(7 8% )、刘 (6 4 % )、赵 (3 7% )、陈 (3 4 % )、孙 (2 8% )、杨 (2 7% )。父母姓氏合并后的前 7位姓氏为 :王 (10 4 2 % )、李 (8 13% )、张 (7 77% )、刘 (6 71% )、赵 (3 5 3% )、杨 (3 36 % )、陈 (3 4 5 % ) ,其分布频率与北方地区人群 (王 9 87%、李 9 2 8%、张 9 13%、刘 6 6 8%、赵 3 5 6 %、杨 3 0 4 %、

A hospital-sampled newborn infant cord blood DNA bank was collected to measure the homogeneity comparing with China and northern China population by distribution of native place and surname.The DNA bank included in 566 cases of newborn infant of Han nation in a hospital in Beijing to sample cord blood,parents’ native place and surname.The parents’ native place and surname were analyzed for distribution,proportion to evaluate their difference with those from China and northern China population data.In the DNA bank,native place of parents from Beijing was from 45.1% to 49.8%,that from Hebei,Shandong,Henan,Jiangsu provinces second from 3.7% to 10.6%,that from other provinces lower than above provinces.The native place of parents covered thirty provinces,municipalities and autonomous regions in China,except Tibet autonomous region and Guizhou province.There were 146 surnames of father and 145 surnames of mother included in the DNA bank.Nine surnames were found more than 1.5% in sampled population.The front eight surnames in order of father were Wang (9.0%),Li (8.0%),Zhang (7.8%),Liu (7.1%),Yang (4.1%),Chen (3.5%),Zhao (3.4%),Gao (1.6%).The front eight surnames in order of mother were Wang (11.8%),Li (8.3%),Zhang (7.8%),Liu (6.4%),Zhao (3.7%),Chen (3.4%),Sun (2.8%),Yang (2.7%).The front seven surnames in order of parents were Wang (10.42%),Li (8.13%),Zhang (7.77%),Liu (6.71%),Zhao (3.53%),Chen (3.45%),Yang (3.36%).The surname distribution of DNA bank was similar to that of north China (Wang 9.87%,Li 9.28%,Zhang 9.13%,Liu 6.68%,Zhao 3.56%,Yang 3.04%,Chen 2.51%) without significance,χ~2=8.54,df=6,P=0.20.The surname in order between DNA bank and northern China was uniform in front fives,the sixth and the seventh reversed.The newborn infant cord blood DNA bank from a hospital in Beijing suggests some feature of the northern China population in surnames.Based on the hospital-sampling stratagem,to modify the sampling method might collect suitable newborn infant cord blood DNA bank to fit for human genetic research.