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氟尿嘧啶抗血管生成作用的实验研究 被引量:9

The experimental study of 5-FU on inhibiting angiogenesis
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摘要 目的 :探讨氟尿嘧啶 (5 FU)的抗血管生成作用。 方法 :以人脐静脉内皮细胞 (HUVEC)原代培养模型 ,MTT法测定 5 FU对HUVEC增殖的影响 ;采用鸡胚尿囊膜血管形成模型 (CAM模型 ) ,观察 5 FU对鸡胚尿囊膜新生血管的抑制作用。 结果 :5 FU在非细胞毒浓度下可在体外抑制HUVEC的增殖 ,在体内抑制鸡胚尿囊膜新生血管形成。 结论 :5 FU在非细胞毒浓度下具有抗血管生成作用。 Objective:To investigate the antiangiogenesis ability of 5 FU. Methods:Human umbilical vein endothelial cells were cultured primarily in vitro and influence of 5 FU on HUVEC proliferation was evaluated by MTT method. Chick chorilallantoic membranes(CAM) model was used to check whether the neovascularization of CAM could be suppressed in vivo . Results:5 FU both inhibited proliferation of HUVEC in vitro and suppressed angiogenesis of CAM in vivo at none cytotoxic doses. Conclusion: 5 FU demonstrated antiangiogenesis ability without obvious cytotoxicity.
出处 《医学研究生学报》 CAS 2004年第5期395-397,共3页 Journal of Medical Postgraduates
关键词 氟尿嘧啶 血管生成 人脐静脉内皮细胞 鸡胚尿囊膜血管形成模型 FU Angiogenesis HUVEC Chick chorioallantoic membrane
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