摘要
肿瘤的快速生长主要依赖于新生血管的形成。血管内皮生长因子(VEGF)在刺激血管内皮细胞生长和诱导血管生成方面起重要作用。肿瘤组织因血管含量丰富,VEGF特异性受体的数目远高于邻近正常组织,因此可以将血管内皮生长因子和某些细胞毒素构建为融合毒素,特异性定位于肿瘤部位,通过抑制血管的增生达到抑制肿瘤的目的。国外自二十世纪九十年代后期开展这方面研究,国内尚少见此类报道。本文就此类融合毒素的设计及临床研究等方面的进展作一综述。
出处
《中国生物制品学杂志》
CAS
CSCD
2004年第3期187-189,共3页
Chinese Journal of Biologicals
参考文献12
-
1Hotz HG, Gill PS, Masood R, et al. Specific targeting of tumor vasculature by diphtheria toxin-vascular endothelial growth factor fusion prtein reduces angiogenesis and growth of pancreatic cancer. J Gastrointes Surg,2002,6(2): 159-166.
-
2Brown L F, Berse B, Jackman R W, et al. Expression of vascular permeability factor(vascular endothelial growth factor)and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res, 1993,53: 4727-4735.
-
3Ramakrisnan S,Olson TA,Bautch VL,et al. Vascular endothelial growth factor-toxin conjugate specifically inhibits KDR/flk-I -positiive endothelial cell proliferation in vitro and angiogenesis in vivo. Cancer Res, 1996,56(6): 1324-1330.
-
4Folkman J. The role of Cangiogenesis in tumor growth. Cancer Biol, 1992,365-371.
-
5Hoffmann S,Masood R,Zhang Y,et al. Selective Killing of PRE with a vascular endothelial growth factor chimeric toxin.Invest Ophthalmol Vis Sci ,2000,41 (8) :2389-2389.
-
6Wild R, Dhanabal M, Olson TA, et al. Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: differential effect on proliferating endothelial cells. Br J cancer,2000,83(8): 1077-1083.
-
7Denekamp J. Endothelial cell proliferation as a novel approach to target ing tumour therapy. J Cancer, 1982,45:136-139.
-
8Plate KH, Breier G, et al. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogen esis. Cancer Res, 1993,53:5822-5827.
-
9Ferrara N, Henzel W. Pituitary follicular cells secrete a novel heparinbinding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun, 1998,161: 851-855.
-
10Tischer E. The human gene for vascular endothelial growth factor: multiple protein froms are endcoded thrugh alternative exon splicing. J Biol Chem, 1991,266:11947-11954.
同被引文献8
-
1Carmeliet P. Angiogenesis in life, disease and medicine. Nature, 2005, 438(7070) :932-936.
-
2Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res, 2006, 312(5) :549-560.
-
3Petersen I. Antiangiogenesis,anti-VEGF(R) and outlook. Recent Results Cancer Res, 2007,176(11) : 189-199.
-
4Manning EA, Ullman JG, Leatherman JM, et al. A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an inenune-based mechanism. Clin Cancer Res, 2007,13 (13) : 3951-3959.
-
5Weigand M, Hantd P, Kreienberg R, et al. Autocfine vascular endothelial growth factor signalling in breast cancer. Evidence from cell lines and primary breast cancer cultures in vitro. Angiogenesis, 2005,8 (3) : 197- 204.
-
6Fuh G, Li B, Crowley C, et al. Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor. J Biol Chem, 1998,273(18) : 11197-11204.
-
7Lu D, Kussie P,Pytowski B,et al. Identification of the residues in the extracelhlar region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR antibodies. J Biol Chem, 2000, 275(19) : 14321-14330.
-
8Xia G, Kumar SR, Hawes D, et al. Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer. J Urol,2006,175 (4) : 1245-1252.
二级引证文献2
-
1张三印,冯蓓,杨苗.当归补血汤抑制与肿瘤共培养血管内皮细胞的增殖及其分子机制[J].中国实验方剂学杂志,2013,19(2):163-167. 被引量：25
-
2杨鹏,冯蓓,杨苗,曾宇,张三印.当归补血汤调控缺氧血管内皮细胞增殖及其分子机制研究[J].中国实验方剂学杂志,2013,19(22):178-181. 被引量：18
-
1黄军,李波,李坚,刘定阳,李岩,Walter A Hall,袁盾.免疫毒素DTATEGF对人非小细胞肺癌脑转移瘤的影响及机制[J].中南大学学报（医学版）,2013,38(12):1217-1222.
-
2陈柳青,曾学思.皮肤T细胞淋巴瘤的系统药物治疗[J].国外医学（皮肤性病学分册）,2002,28(2):76-79. 被引量：6
-
3在Ⅰ期临床试验中的新抗癌剂[J].德国临床用药,1999,2(4):5-6.
-
4张国驰.细菌和宿主细胞蛋白酶对细菌毒素的激活作用[J].国外医学（微生物学分册）,1994,17(6):266-269.
-
5黄军,蒋星军,李波,龙小艳,李岩,WalterAHall.双重靶向毒素DTATEGF对裸小鼠皮下及脑内人乳腺癌脑转移瘤的疗效[J].中华实验外科杂志,2013,30(4):671-673.
-
6郭丽丽.微卫星DNA异常改变与肺癌诊断的研究进展[J].结核病与胸部肿瘤,2005(2):79-84.
-
7屈海燕,乔文.环氧合酶-2、血管内皮细胞生长因子和血管内皮生长因子C在胃癌中的表达及意义[J].中国医药导报,2015,12(17):16-19. 被引量：3
-
8王勇,刘益飞,章建国.血管内皮细胞生长因子和血管生成素-2在喉癌中表达及意义[J].交通医学,2013,27(5):442-445. 被引量：1
-
9柴映爽,程新,姚立红,陈爱珺,喻宏,严馨蕊,贾润清,黄国锦,张智清.靶向毒素DT-VEGF的构建、表达与活性分析[J].生物工程学报,2004,20(2):192-196. 被引量：2
-
10沈诚,范士志,蒋耀光.血管内皮细胞生长因子及临床应用策略[J].国外医学（分子生物学分册）,2003,25(1):6-9. 被引量：7
