SARS冠状病毒M蛋白HLA-A*0201限制性CTL表位的预测

Prediction of HLA-A*0201-restricted CTL epitopes in SARS-CoV M protein

目的 预测SARS冠状病毒M蛋白的HLA A 0 2 0 1限制性CTL表位。方法 联合应用简单基序法和延展基序法。结果 预测出 4个九肽CTL表位。结论 通过对SARS冠状病毒M蛋白抗原CTL表位进行预测 ,从而为SARS冠状病毒M蛋白CTL表位的实验探测和鉴定提供了线索 。

Objective To predict the HLA-A*0201-restricted CTL epitopes(nonamers) in SARS-CoV M protein. Methods The CTL epitopes of M protein were predicted by using simple motif method combined with expanded motif method. Results Four HLA-A*0201-restricted CTL epitope candidates were predicted in SARS-CoV M protein. Conclusion The prediction of the CTL epitopes in SARS-CoV M protein will benefit the identification of CTL epitopes by experiment. Those results are of importance for immune recognition and vaccine design for SARS-CoV.